4-Sulfonamidoanilide tertiary carbinols: A novel series of potassium channel openers

…, D Mayhugh, CJ Ohnmacht, CA Frank, T Grant…

文献索引：Empfield; Mayhugh; Ohnmacht; Frank; Grant; Li Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 7 p. 775 - 778

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被引用次数: 9

摘要

Sulfonamides are viable replacements for the phenylsulfonyl and benzoyl moieties initially described for the anilide tertiary carbinol series of KATP potassium channel openers. The SAR of this new series and the synthetic chemistry employed to generate its members are described.