Journal of medicinal chemistry

The Synthesis of 4, 5-Dimethyl-1, 2-benzanthracene and 4, 5, 10-Trimethyl-1, 2-benzanthracene1

MS Newman, S Blum

文献索引：Newman,M.S.; Blum,S. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 466 - 468

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被引用次数: 7

摘要

The condensation of 3-methylphthalic anhydride with 3-methyl-1-naphthylmagnesium bromide afforded the acids 111 and IV in 33 and 14yo yield." The mixture of acids 111 and IT'was separated by converting it into the corresponding normal methyl ester mixture by treating with diazomethane. Dissolution of these esters in concentrated sulfuric acid followed by dilution with water afforded I11 as acid and IV as methyl ester. h clean separation was ...