Synthesis and protein kinase C inhibitory activities of balanol analogues with modification of 4-hydroxybenzamido moiety
H Hu, JS Mendoza, CT Lowden, LM Ballas…
文献索引：Hu, Hong; Mendoza, Jose S.; Lowden, Christopher T.; Ballas, Lawrence M.; Janzen, William P. Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 9 p. 1873 - 1882
A series of racemic balanol analogues with modification of the benzamido moiety of balanol have been synthesized and evaluated for their inhibitory activities against human protein kinase C isozymes (PKC-alpha,-beta I,-beta II,-gamma,-delta,-epsilon, and-eta). The structural modification includes replacement of the 4-hydroxyphenyl group with variously substituted phenyl rings, substitution of the amide linkage with a sulfonamide or an ester, ...
