Bioorganic chemistry

Synthesis and anti-inflammatory activity of benzophenone analogues

SA Khanum, S Shashikanth, AV Deepak

文献索引：Khanum, Shaukath A.; Shashikanth, Sheena; Deepak Bioorganic Chemistry, 2004 , vol. 32, # 4 p. 211 - 222

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被引用次数: 47

摘要

A series of substituted benzophenone analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indomethacin, and phenylbutazone. In carrageenan-induced foot pad edema assay, benzophenone analogues showed an interesting anti-inflammatory activity. In the air-pouch test, some of the ...