Certain 4-Hydroxyquinolines from Aniline and β-Ketonitriles. Cyclizations of Nitriles through Amides by Means of Polyphosphoric Acid

CR Hauser, JG Murray

文献索引：Hauser; Murray Journal of the American Chemical Society, 1955 , vol. 77, p. 2851

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被引用次数: 15

摘要

It should be pointed out that the cyclization of anil-amide IX must not involve dehydration to form the corresponding amine (XI) followed by hydrolysis, since this amine was shown to be stable under similar conditions. Amine XI was prepared from IT by means of phosphorus oxychloride and ammonia. One attempt to prepare it from anilamide IX by means of phosphorus pentoxide was unsuccessful. A similar cyclization, involving dehydration, has ...