Enzymatic optical resolution of norbornanecarboxylic esters using pig liver esterase

…, AJH Klunder, B Zwanenburg

文献索引：Gastel, F. J. C. van; Klunder, A. J. H.; Zwanenburg, B. Recueil des Travaux Chimiques des Pays-Bas, 1991 , vol. 110, # 5 p. 175 - 184

全文：HTML全文

被引用次数: 11

摘要

Abstract The hydrolysis of a series of norbornane-type carboxylic esters catalyzed by pig liver esterase (PLE) has been investigated. It was found that an exo-eer function (syn to the C7 methylene group) is hydrolyzed with high preference. Enantioselective hydrolysis can be accomplished when a vicinal carbonyl-containing function (eer, formyl, acetyl) is present in a trans position with respect to the exo eer. The regiospecificity of the enzymatic hydrolysis ...