Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease

…, XB Wang, WY Yu, SS Xie, SY Li, LY Kong

文献索引：Xu, Zi-Chen; Wang, Xiao-Bing; Yu, Wen-Ying; Xie, Sai-Sai; Li, Su-Yi; Kong, Ling-Yi Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2368 - 2373

全文：HTML全文

被引用次数: 5

摘要

Abstract A novel series of benzylisoquinoline derivatives were designed, synthesized, and evaluated as multifunctional agents against Alzheimer's disease (AD). The screening results showed that most of the compounds significantly inhibited cholinesterases (ChEs), human cholinesterases (h-ChEs) and self-induced β-amyloid (Aβ) aggregation. In particular, compound 9k showed the strongest acetylcholinesterase (AChE) inhibitory activity, being ...