New 1, 4-dihydropyridine derivatives combining calcium antagonism and. alpha.-adrenolytic properties

G Marciniak, A Delgado, G Leclerc, J Velly…

文献索引：Marciniak; Delgado; Leclerc; Velly; Decker; Schwartz Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1402 - 1407

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被引用次数: 88

摘要

A series of twelve 1, 4-dihydropyridine derivatives incorporating an a-adrenergic moiety in one of the ester chains was synthesized. The compounds were evaluated for their calcium antagonist activities by the inhibition of [3H] nitrendipine binding and, in vitro, on pig coronary artery. Their al-and a,-adrenolytic effects were assessed from their inhibition of [3H] prazosin and [3H] yohimbine binding and, in vitro, on rat aorta and guinea pig vas ...