Design, synthesis and antiinflammatory activity of some 1, 3, 4-oxadiazole derivatives

FA Omar, NM Mahfouz, MA Rahman

文献索引：Omar; Mahfouz; Rahman European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 819 - 825

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被引用次数: 274

摘要

A series of substituted 1, 3, 4-oxadiazole derivatives 19–34 were synthesized as antiinflammatory agents. The target compounds were obtained by cyclodesulfurization of the corresponding thiosemicarbazides 3–18 using either dicyclohexylcarbodiimide DCC, or I2/NaOH. Intermediates 3–18 are readily accessible through conversion of the carboxylic acids 1a-d to the respective hydrazides 2a–d followed by treatment with appropriate ...