Journal of medicinal chemistry

Enamine derivatives of malonic acid with pharmacologic activities

AA Santilli, WF Bruce, TS Osdene

文献索引：Santilli,A.A. et al. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 68 - 72

被引用次数: 17

摘要

A number of enamines corresponding to 11 have tieen prepared mti ch: tr: tc, terizetl. Alariy of these compounds displayed muscle relaxant, and sedative properties when tested in mire. 1ledrlc: tiori of diethyl (4-h>-(lruxy-4-phenylpiperidyl) riiethylenernalonate with lithium: tlunrinuni hydride gave 2-(~-hydr (isy-l-phen?. lpiperidyl)-2-propen-1-ol. Cat &lytic hydrogenation of diethyl~ iperidylniethyle~ iernal (~~ iate resulted in the reductive ( ...