Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives

…, G Panda, V Chaturvedi, YS Manju, AK Gaikwad…

文献索引：Das, Sajal Kumar; Panda, Gautam; Chaturvedi, Vinita; Manju; Gaikwad, Anil K.; Sinha, Sudhir Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5586 - 5589

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被引用次数: 29

摘要

A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel–Crafts alkylation on 1-and 2- naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro and showed MIC in the range of 3.12–25μg/ml.