Studies on the inhibition of Moloney murine leukemia virus reverse transcriptase by N-tritylamino acids and N-tritylamino acid-nucleotide compounds

…, P Van der Bijl, M Van der Merwe, W Nel…

文献索引：Hawtrey, Arthur; Pieterse, Anton; Van Zyl, Johann; Van Der Bijl, Pieter; Van Der Merwe, Marichen; Nel, William; Ariatti, Mario Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 9 p. 1011 - 1023

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摘要

N-Acylated derivatives of 8-(6-aminohexyl) amino-adenosine-5′-phosphate were prepared and studied with regard to their effect on DNA synthesis by the Moloney leukemia virus reverse transcriptase. N-palmitoyl and N-nicotinyl derivatives and bis-8-(6-aminohexyl) amino-5′-AMP inhibited the enzyme partially using poly (rA). oligo d (pT) 16-18 as template- primer with [3H] dTTP. In order to increase hydrophobicity in the acyl component tethered ...