Antitumor agents—CLXVII. Synthesis and structure-activity correlations of the cytotoxic anthraquinone 1, 4-bis-(2, 3-epoxypropylamino)-9, 10-anthracenedione, and of …

…, J Koyama, SL Morris-Natschke, A Mauger…

文献索引：Johnson, Mary G.; Kiyokawa, Hiroshi; Tani, Shohei; Koyama, Junko; Morris-Natschke, Susan L.; Mauger, Anthony; Bowers-Daines, Margaret M.; Lange, Barry C.; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1469 - 1479

全文：HTML全文

被引用次数: 34

摘要

1, 4-Bis-(2, 3-epoxypropylamino)-9, 10-anthracenedione (3) was synthesized in this laboratory and was found to be a potent antitumor agent. Derivatives of this compound containing anthraquinone, naphthoquinone, and quinone skeletons were also prepared and evaluated for in vitro cytotoxic activity in several cell lines. These molecules were designed as bifunctional antitumor agents with the potential to act as (1) intercalating agents due to ...