… acetophenones against P388 lymphocytic leukemia and toxicological assessment of 3??dimethyl??amino??2??dimethylaminomethyl??1??(4??methoxyphenyl)??1??propanone …

JR Dimmock, K Shyam, BM Logan…

文献索引：Dimmock; Shyam; Logan; Smith; Cross Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 4 p. 471 - 477

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被引用次数: 8

摘要

Abstract A number of analogues of 3-dimethylamino-2-dimethylaminomethyl-1-(4- methoxyphenyl)-1-propanone dihydrochloride (IIa) and related compounds which showed activity against P388 lymphocytic leukemia were prepared, and of the 16 analogues, three met the criterion for activity in this screen. The toxicity of IIa was examined in rats and either a single dose of 25 mg/kg or nine daily doses of 12.5 mg/kg administered by the intra- ...