Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents

…, M Curini, M Dudra-Jastrzebska, JJ Luszczki

文献索引：Genovese, Salvatore; Epifano, Francesco; Curini, Massimo; Dudra-Jastrzebska, Monika; Luszczki, Jarogniew J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 18 p. 5419 - 5422

全文：HTML全文

被引用次数: 22

摘要

In this study, we synthesized some natural and semi-synthetic prenyloxyphenylpropanoids (eg, acetophenones, benzoic and cinnamic acids, chalcones, and coumarins), and we assessed their in vivo neuroprotective activity, using the mouse maximal electroshock- induced seizure model (MES test). 7-Isopentenyloxycoumarin and (2E)-3-{4-[(3-methylbut-2- enyl) oxy] phenyl} prop-2-enoic acid, administered ip at a dose of 300mg/kg, suppressed ...