Efficient" one-pot" synthesis of N-tritylamino acids

…, D Papaioannou, D Theodoropoulos

文献索引：Barlos, Kleomenis; Papaioannou, Dionysios; Theodoropoulos, Dimitrios Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1324 - 1326

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被引用次数: 121

摘要

A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity. Hydroxy amino acids 4 were preferentially tritylated at the amino function by using either MeaSiCl or Me $ iClz (or Ph $ iC12) for temporary protection of the hydroxy and carboxyl groups. Finally, P-tritylhistidine (9c) was prepared in 97% ...