Tetrahedron letters

A novel procedure for conversion of epoxides to α-hydroxyphosphonates with a trialkylphosphite mediated by LiClO 4

N Azizi, MR Saidi

文献索引：Azizi, Najmoddin; Saidi, Mohammad R. Tetrahedron Letters, 2003 , vol. 44, # 43 p. 7933 - 7935

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被引用次数: 15

摘要

A new method has been developed for the direct conversion of epoxides to α- hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions.