Synthesis and central dopaminergic effects of N-(4, 6-dimethyl-2-pyridinyl) benzamides

…, S Piessard, GL Baut, L Sparfel, JY Petit…

文献索引：Bouhayat, Said; Piessard, Sylvie; Baut, Guillaume Le; Sparfel, Louis; Petit, Jean-Yves; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 555 - 559

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被引用次数: 8

摘要

30-33 iodide, ll the reaction with methyl trifluoromethanesulfonate, at 60 OC, was sluggish and the pyridinyl nucleus underwent partial quaternization. It was possible to carry out methylation of 1 by prolonged heating with methyl iodide in a sealed tube (method E), but the yield was moderate. For tertiary benzamides 30-33, an alternative synthesis was achieved by benzoylation of the secondary amines 27, 28, as outlined in Scheme I1 ( ...