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Tetrahedron Letters

Facile syntheses of 1-deoxynojirimycin (DNJ) and 1-deoxymannojirimycin (DMJ)

X Song, RI Hollingsworth

文献索引:Song, Xuezheng; Hollingsworth, Rawle I. Tetrahedron Letters, 2007 , vol. 48, # 17 p. 3115 - 3118

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被引用次数: 16

摘要

1-Deoxynojirimycin (DNJ) and 1-deoxymannojirimycin (DMJ) were synthesized through a concise and practicable pathway. A strategy of using carbohydrate derivatives bearing two leaving groups in the preparation of azasugars by di-N-alkylation of amines was developed. The strategy involved the selective partial protection of dibromo alditols.