Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt (III) …

…, BD Palmer, WR Wilson, WA Denny

文献索引：Ware; Palmer; Wilson; Denny Journal of Medicinal Chemistry, 1993 , vol. 36, # 13 p. 1839 - 1846

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被引用次数: 162

摘要

Nitrogen mustards coordinated to Co (II1) are potential hypoxia-selective cytotoxins, since oneelectron reduction to the Co (I1) complexes greatly labilizes the Co-N bonds, causing the release of activated aliphatic mustards which can act as diffusible cytotoxins. Two series of Co (II1) complexes of the bidentate bisalkylating nitrogen mustard ligands N,"-bis (2- chloroethyl)-ethylenediamine (BCE) and Nfl-bis (2-chloroethy1) ethylenediamine (DCE) ...