A Stereospecific Synthesis of Biotin from an Aromatic Precursor. Preliminary Communication

PN Confalone, G Pizzolato…

文献索引：Confalone; Pizzolato; Uskokovic Helvetica Chimica Acta, 1976 , vol. 59, # 4 p. 1005 - 1008

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被引用次数: 14

摘要

The required differentiation of the diacid functionality of compound 7 is achieved by selective lactam formation with the terminal acid to yield the 8-membered lactam 8. A modified Curtius reaction then affords the rearranged diurethane 18 through a series of acyl transfers. Finally,