Total Synthesis of Umuravumbolide

…, DK Reddy, Y Venkateswarlu

文献索引：Shekhar, Vanam; Reddy, Dorigondla Kumar; Venkateswarlu, Yenamandra Helvetica Chimica Acta, 2012 , vol. 95, # 9 p. 1593 - 1599

全文：HTML全文

被引用次数: 4

摘要

Abstract A simple and efficient stereoselective total synthesis of (+)-umuravumbolide (1b) and (−)-deacetylumuravumbolide (1a) starting from commercially available pentanal is described. The synthesis involves Sharpless asymmetric epoxidation, Jacobsen's hydrolytic kinetic resolution (HKR), and the Yamaguchi oxirane opening as key steps (Scheme 2).