Synthesis and antitumor activity of 1, 8-diaminoanthraquinone derivatives

HS Huang, HF Chiu, WC Lu, CL Yuan

文献索引：Huang, Hsu-Shan; Chiu, Hui-Fen; Lu, Wei-Chih; Yuan, Chun-Lung Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 9 p. 1136 - 1139

全文：HTML全文

被引用次数: 25

摘要

Continuing our ongoing studies on cytotoxic substances, a series of regioisomeric disubstituted aminoanthraquinone (DAAQ) derivatives have been synthesized as cytotoxic activity based on a proposed bioactive amino conformation. To assess the biological activity of amino-substitution in the side-chains of anthraquinone located at positions 1 and 8 of the anthraquinone ring system. The aim of the study was to determine if members of the ...