Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities

…, A Fournet, JC Gantier, R Hocquemiller

文献索引：Soriano-Agaton, Flor; Lagoutte, Delphine; Poupon, Erwan; Roblot, Francois; Fournet, Alain; Gantier, Jean-Charles; Hocquemiller, Reynald Journal of Natural Products, 2005 , vol. 68, # 11 p. 1581 - 1587

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被引用次数: 46

摘要

Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin- 6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.