Tetrahedron

Novel synthesis of indolizidines and quinolizidines

KA Tehrani, M D'hooghe, N De Kimpe

文献索引：Tehrani, Kourosch Abbaspour; D'hooghe, Matthias; De Kimpe, Norbert Tetrahedron, 2003 , vol. 59, # 17 p. 3099 - 3108

全文：HTML全文

被引用次数: 32

摘要

A very short synthesis of indolizidines, quinolizidines and some higher homologues was developed by alkylation of 2-methyl-1-pyrroline or 6-methyl-2, 3, 4, 5-tetrahydropyridine with 1, 3-or 1, 4-dihaloalkanes, followed by reduction of the intermediate iminium salts, resulting in the desired 1-azabicyclo [mn 0] alkanes in good yields.