Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast Schizosaccharomyces pombe

…, D Buchheit, D Bischoff, T Ebner, M Bureik

文献索引：Dragan, Calin-Aurel; Buchheit, Daniela; Bischoff, Daniel; Ebner, Thomas; Bureik, Matthias Drug Metabolism and Disposition, 2010 , vol. 38, # 3 p. 509 - 515

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被引用次数: 21

摘要

Abstract Drug metabolites generated by UDP glycosyltransferases (UGTs) are needed for drug development and toxicity studies, especially in the context of safety testing of metabolites during drug development. Because chemical metabolite synthesis can be arduous, various biological approaches have been developed; however, no whole-cell biotransformation with recombinant microbes that express human UGTs was yet achieved. ...