Nitric oxide donor β2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans

MF Buonsanti, M Bertinaria, A Di Stilo…

文献索引：Federica Buonsanti; Bertinaria, Massimo; Di Stilo, Antonella; Cena, Clara; Fruttero, Roberta; Gasco, Alberto Journal of Medicinal Chemistry, 2007 , vol. 50, # 20 p. 5003 - 5011

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被引用次数: 18

摘要

The structure of fenoterol, a β2-adrenoceptor agonist used in therapy, has been joined with furoxan NO-donor moieties to give new NO-donor β2-agonists. The furazan analogues, devoid of the property to release NO, were also synthesized for comparison. All the compounds retained β2-agonistic activity at micromolar or submicromolar concentration when tested on guinea pig tracheal rings precontracted with carbachol. Among the ...