Carbonylative coupling of organozinc reagents in the presence and absence of aryl iodides: synthesis of unsymmetrical and symmetrical ketones

RFW Jackson, D Turner, MH Block

文献索引：Jackson, Richard F. W.; Turner, Debra; Block, Michael H. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 865 - 870

全文：HTML全文

被引用次数: 41

摘要

The utility of the palladium (0) catalysed reaction of the iodoalanine-derived organozinc reagent 6a with functionalised aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo α-amino acids 8, is illustrated by a short synthesis of L-kynurenine 4. Treatment of functionalised organozinc reagents with catalytic tetrakis (triphenylphosphine) palladium (0) under an atmosphere of carbon monoxide in the absence of any ...