Organic letters

Ethyl 2-chlorooxazole-4-carboxylate: a versatile intermediate for the synthesis of substituted oxazoles

KJ Hodgetts, MT Kershaw

文献索引：Hodgetts, Kevin J.; Kershaw, Mark T. Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907

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被引用次数: 62

摘要

By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions, the synthesis of variously substituted oxazoles from ethyl 2-chlorooxazole-4- carboxylate (2) was accomplished. The methodology was applied to the synthesis of a series of 2, 4-disubstituted, 2, 5-disubstituted, and 2, 4, 5-trisubstituted oxazoles.