Enantiospecific total synthesis of the sesquiterpene antibiotics (-)-punctatin A and (+)-punctatin D

T Sugimura, LA Paquette

文献索引：Sugimura; Paquette Journal of the American Chemical Society, 1987 , vol. 109, # 10 p. 3017 - 3024

全文：HTML全文

被引用次数: 84

摘要

Abstract: Total syntheses of the levorotatory enantiomer of punctatin A (antibiotic M95464) and the dextrorotatory enantiomer of punctatin D (antibiotic M167906) have been achieved. The identities of the synthetic materials with the corresponding natural products, which were confirmed spectroscopically and by [a] D, permitted the assignment of absolute configuration. These structurally novel trans fused tertiary cyclobutyl alcohol antibiotics ...