Synlett

A concise route to the key intermediate of (+)-vernolepin using a bicyclo [3.2. 1] octane chiral building block

N Miyazawa, K Ogasawara

文献索引：Miyazawa, Norio; Ogasawara, Kunio Synlett, 2002 , # 7 p. 1065 - 1068

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被引用次数: 7

摘要

Abstract An enantioselective route to the key intermediate leading to (+)-vernolepin, an antitumor sesquiterpene, isolated from Vernonia hymenolepis, has been developed starting from the chiral building block having a bicyclo [3.2. 1] octane framework accessible by either enzymatic or catalytic kinetic resolution.