Antiinflammatory activity of substituted 6-hydroxypyrimido [2, 1-f] purine-2, 4, 8 (1H, 3H, 9H)-triones. Atypical nonsteroidal antiinflammatory agents

DJ Blythin, JJ Kaminski, MS Domalski…

文献索引：Blythin; Kaminski; Domalski; Spitler; Solomon; Conn; Wong; Verbiar; Bober; Chiu Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1099 - 1113

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被引用次数: 33

摘要

A novel class of antiinflammatory drugs, which are substituted derivatives of the fused tricyclic system 6-hydroxypyrimido [2, 1-flpurine-2, 4, 8 (lH, 3H, 9H)-trione (see, for instance, Table 111), is described. Synthetic procedures and structure determination with the assistance of X-ray crystallography are discussed. Semiempirical molecular orbital calculations are used to investigate the relative stability of the possible isomers and ...