Tetrahedron

C-2 Functionalized N 6-cyclosubstituted adenosines: Highly selective agonists for the adenosine A 1 receptor

V Nair, AJ Fasbender

文献索引：Nair, Vasu; Fasbender, Allen J. Tetrahedron, 1993 , vol. 49, # 11 p. 2169 - 2184

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被引用次数: 28

摘要

Synthesis of novel N6-cyclosubstituted isoguanosines and related C-2 functionalized compounds utilizing methodologies with key thermal radical and photochemical steps developed in our laboratory is described. Data on the affinities of these new compounds for the adenosine A1 and A2 receptors clearly show that a number of N6-cyclosubstituted isoguanosines show excellent A1 agonist activity with the best activity and selectivity ...