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1, 2-Dithiolan-3-ones and derivatives structurally related to leinamycin. Synthesis and biological evaluation

R Salvetti, G Martinetti, D Ubiali, M Pregnolato…

文献索引：Salvetti, Raul; Martinetti, Giovanni; Ubiali, Daniela; Pregnolato, Massimo; Pagani, Giuseppe Farmaco, 2003 , vol. 58, # 9 p. 995 - 998

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被引用次数: 5

摘要

Leinamycin, an antitumor antibiotic isolated from Streptomyces sp., shows a 1, 2-dithiolan-3- one 1-oxide heterocycle that appears to be involved in the biological activity. Several derivatives related to 1, 2-dithiolan-3-one 1-oxide have been prepared and their activity as antineoplastic agents have been investigated. The synthesized compounds did not display a significative antitumor or cytotoxic activity in vitro.