Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4, 6-bis [(phosphonomethoxy) alkoxy] pyrimidines

P Doláková, M Dračínský, M Masojídková…

文献索引：Dolakova, Petra; Dracinsky, Martin; Masojidkova, Milena; Solinova, Veronika; Kasicka, Vaclav; Holy, Antonin European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2408 - 2424

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被引用次数: 28

摘要

2-Amino-4, 6-bis [(phosphonomethoxy) alkoxy] pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4, 6-dichloropyrimidine or by alkylation of 4, 6-dihydroxy- 2-(methylsulfanyl) pyrimidine with appropriate phosphonate-bearing building block. Alkylation of 4, 6-dihydroxy-2-(methylsulfanyl) pyrimidine proved to be the method of ...