Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling …

AEA Hassan, RAI Abou-Elkhair, JM Riordan…

文献索引：Hassan, Abdalla E.A.; Abou-Elkhair, Reham A.I.; Riordan, James M.; Allan, Paula W.; Parker, William B.; Khare, Rashmi; Waud, William R.; Montgomery, John A.; Secrist III, John A. European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 167 - 174

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被引用次数: 10

摘要

A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-d-ribofuranosyl) purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E. coli PNP) were evaluated.(Ph3P) 4Pd-mediated cross-coupling reactions of 6-chloro-9-(2, 3, 5-tri-O- acetyl-β-d-ribofuranosyl)-purine (6) with primary alkyl (Me, Et, n-Pr, n-Bu, isoBu) zinc halides followed by treatment with NH3/MeOH gave the corresponding 6-alkyl-9-(β-d- ...