Rhodium??Catalyzed Homogeneous Reductive Amidation of Aldehydes

S Raoufmoghaddam, E Drent…

文献索引：Raoufmoghaddam, Saeed; Drent, Eite; Bouwman, Elisabeth Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 717 - 733

全文：HTML全文

被引用次数: 11

摘要

Abstract The catalytic reductive amidation of an aldehyde (hexanal) with an amide (acetamide) is reported. Apart from the desired N-hexylacetamide, the two isomeric unsaturated intermediates as well as hexanol are produced together with higher mass products that arise from aldol condensation and diamide coupling of the aldehyde. Screening of different catalyst precursor salts, ligands and reaction conditions led to the ...