NMR Method for Simultaneous Host–Guest Binding Constant Measurement

…, K Haav, L Toom, T Haljasorg, I Leito

文献索引：Kadam, Sandip A.; Haav, Kristjan; Toom, Lauri; Haljasorg, Toiv; Leito, Ivo Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2501 - 2513

全文：HTML全文

被引用次数: 3

摘要

An NMR-based relative binding affinity measurement method has been developed in which differences in the binding affinities of different hosts toward a particular guest (Δlog K ass values) are measured in the same solution. As an advancement, the method allows the simultaneous determination of several Δlog K ass values in a single run. As a proof of principle, the method was used to measure binding affinity differences of a number of ...