Journal of heterocyclic chemistry

Novel perfluoroalkyl??substituted pyrazoles. 1. Hydroxypyrazoles

BJ Gaede, LL Mcdermott

文献索引：Gaede, Bruce J.; McDermott, Lisa L. Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 1 p. 49 - 54

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被引用次数: 36

摘要

Abstract Addition of methylhydrazine to a variety of haloalkyl-substituted α, β-unsaturated esters gives 1, 5-disubstituted 3-hydroxypyrazoles, in contrast to the more common synthesis from β-ketoesters, which gives 1, 3-disubstituted 5-hydroxypyrazoles. This reaction is used to prepare several novel pyrazoles bearing haloalkyl substituents. Criteria for assignment of structures have been developed based on physical and spectroscopic ...