Molecular design of antifungal agents

…, P Xiao, K Nihei, K Fujita, Y Yamagiwa…

文献索引：Kubo, Isao; Xiao, Ping; Nihei, Ken-Ichi; Fujita, Ken-Ichi; Yamagiwa, Yoshiro; Kamikawa, Tadao Journal of Agricultural and Food Chemistry, 2002 , vol. 50, # 14 p. 3992 - 3998

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被引用次数: 43

摘要

In a rational approach to the design of antifungal agents against Saccharomyces cerevisiae, a series of alkyl gallates (3, 4, 5-trihydroxybenzoates) were synthesized and assayed. Nonyl gallate (1) was found to be the most effective with a minimum fungicidal concentration (MFC) of 12.5 μg/mL (42 μM), followed by octyl gallate (2) with an MFC of 25 μg/mL (89 μM). These MFCs are little influenced by pH values. A time-kill curve study indicates that nonyl gallate ...