Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp.
…, PB Little, DS Millan, AT Plowright, JA Tornos…
文献索引：Pattenden, Gerald; Gonzalez, Miguel A; Little, Paul B; Millan, David S; Plowright, Alleyn T; Tornos, James A; Ye, Tao Organic and biomolecular chemistry, 2003 , vol. 1, # 23 p. 4173 - 4208
A convergent total synthesis of phorboxazole A (1a), from the C (3–19), C (20–27) and C (33– 46) fragments 5, 4 and 91, respectively, concentrating on stereocontrolled formation of the bonds at C (2–3), C (19–20) and C (27–28), is described. Although a coupling reaction between a macrolide ketone and the side chain substituted sulfone, at C (27–28) was not successful, a Wadsworth–Emmons olefination involving the oxane methyl ketone 4 and an ...
