Synthesis and anticancer activity of oxindole derived imidazo [1, 5-a] pyrazines

…, G Ramakrishna, P Raju, AVS Rao, A Viswanath…

文献索引：Kamal, Ahmed; Ramakrishna; Raju; Rao, A.V. Subba; Viswanath; Nayak, V. Lakshma; Ramakrishna, Sistla European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2427 - 2435

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被引用次数: 37

摘要

Abstract A series of oxindole derivatives of imidazo [1, 5-a] pyrazines were prepared and confirmed by 1 H NMR, mass and HRMS data. These compounds were evaluated for their anticancer activity against a panel of 52 human tumor cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Among them compound 7l showed significant anticancer activity with GI 50 values ranging ...

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