Chemistry Letters

Solvent-free coumarin synthesis

T Sugino, K Tanaka

文献索引：Sugino, Teizo; Tanaka, Koichi Chemistry Letters, 2001 , # 2 p. 110 - 111

全文：HTML全文

被引用次数: 80

摘要

Coumarin derivatives are important chemicals in the per- fume, cosmetic, agricultural and pharmaceutical industries.1 However, the conventional methods for coumarin synthesis require drastic conditions. For example, 4-methyl-7-hydroxy- coumarin has been prepared by stirring a mixture of resorcinol and ethyl acetoacetate in concd H2SO4 for 12–24 h.2 ... To an equivalent mixture of resorcinol (1a, 1.1 g, 10.0 mmol) and ethyl acetoacetate (2a, 1.3 g, 10.0 mmol) was ...