Synthesis of (1??(Aminomethyl)??2, 3??dihydro??1 H??inden??3??yl) methanol: Structural Confirmation of the Main Band Impurity Found in Varenicline® Starting Material
…, RE Handfield, JD McKinley, ME McMahon…
文献索引：Busch, Frank R.; Concannon, Paul E.; Handfield, Robert E.; McKinley, Jason D.; McMahon, Megan E.; Singer, Robert A.; Watson, Timothy J.; Withbroe, Gregory J.; Stivanello, Mariano; Leoni, Lucia; Bezze, Chiara Synthetic Communications, 2008 , vol. 38, # 3 p. 441 - 447
Abstract Described here is the synthesis of (1??(aminomethyl)??2, 3??dihydro??1 H??inden??3??yl) methanol 1, the previously unidentified impurity found in the synthesis of 2, 1 providing a confirmation of the structure. Fabbrica Italiano Sintetici (FIS), working in conjunction with Pfizer Groton, reported an unidentified impurity, referred to as the “main band impurity”, in 2 at levels of 0.4 to 0.8%. The structure was postulated to be 1, the open??ring product of the ...
