Engineering of highly luminescent lanthanide tags suitable for protein labeling and time-resolved luminescence imaging

N Weibel, LJ Charbonnière, M Guardigli…

文献索引：Weibel, Nicolas; Charbonniere, Loic J.; Guardigli, Massimo; Roda, Aldo; Ziessel, Raymond Journal of the American Chemical Society, 2004 , vol. 126, # 15 p. 4888 - 4896

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被引用次数: 242

摘要

The synthesis of a new ligand L H4 based on a glutamic acid skeleton bis-functionalized on its nitrogen atom by 6-methylene-6'-carboxy-2, 2'-bipyridine chromophoric units is described. UV-vis spectrophotometric titrations revealed the formation of 1: 1 M: L complexes with lanthanide (III) cations, and complexation of L H4 with equimolar amounts of hydrated LnCl3 salts (Ln= Eu, Gd, and Tb) gave water-soluble and stable complexes of the general ...