Synthesis and pharmacological profile of a series of 2, 5-substituted-N, N-dimethyltryptamine derivatives as novel antagonists for the vascular 5-HT 1B-like receptor

GP Moloney, GR Martin, PY Sang…

文献索引：Moloney, Gerard P.; Martin, Graeme R.; Mathews, Neil; Hobbs, Heather; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Maxwell, Miles; Glen, Robert C. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2713 - 2723

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被引用次数: 14

摘要

The coronary 5-HT1B-like receptor has been implicated in vasospasm and it is postulated that a 5-HT1B-like antagonist may block the detrimental action of 5-HT whilst not interfering with normal blood vessel function. The synthesis and pharmacological profile of a novel series of 2-(N-heteroaryl) carboxamido-5-substituted-N, N-dimethyltryptamine derivatives as silent (as judged by the inability of angiotensin II to unmask 5-HT1B-like receptor ...