Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives

YC Chang, J Herath, THH Wang, CS Chow

文献索引：Chang, Yu-Cheng; Herath, Jayatilake; Wang, Tony H.-H.; Chow, Christine S. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2676 - 2686

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被引用次数: 14

摘要

A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating ...