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Process development and large-scale synthesis of a PDE4 inhibitor

DA Conlon, A Drahus-Paone, GJ Ho…

文献索引:Organic Process Research and Development, , vol. 10, # 1 p. 36 - 45

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被引用次数: 30

摘要

... Rahway, New Jersey 07065-0900, USA, and Medicinal Chemistry Department, Merck Frosst Centre for Therapeutic Research, PO Box ... 5 In fact, a quote from the Organic Reactions review states that the conditions under which the earlier ... Scheme 2. Skraup reaction process. ...