Synthesis and antibacterial activity of 5-methoxy-and 5-hydroxy-6-fluoro-1, 8-naphthyridone-3-carboxylic acid derivatives

TM Hansen, YG Gu, TM Rehm, PJ Dandliker…

文献索引：Hansen, T. Matthew; Gu, Yu-Gui; Rehm, Tamara M.; Dandliker, Peter J.; Chovan, Linda E.; Bui, Mai H.; Nilius, Angela M.; Beutel, Bruce A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2716 - 2719

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被引用次数: 9

摘要

A series of 5-methoxy-and 5-hydroxy-6-fluoro-1, 8-naphthyridone-3-carboxylic acid derivatives were prepared and evaluated for cell-free bacterial protein synthesis inhibition and whole cell antibacterial activity. When compared to the analogous 5-hydrogen compounds, the presence of the 5-OH group negatively affects biochemical potency. However, a tolerance of the 5-methoxy group is indicated. Only moderate whole cell ...