Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles

…, R Wang, E Bagan, CC Wang, P Wislocki…

文献索引：Walsh; Wang; Bagan; Wislocki; Miwa Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 150 - 156

全文：HTML全文

被引用次数: 55

摘要

Two approaches have been used to develop nonmutagenic 5-nitroimidazoles. Both approaches are based on knowledge of the likely mechanisms by which this class of compounds cause mutagenicity. The first approach involved incorporating readily oxidizable gallate derivatives into the molecule. In one case, a very weakly mutagenic active antitrichomonal agent was obtained. The second approach involved incorporating a ...